Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 12/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | RHOC | P08134 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857125 | 0.99 | HMGCR (0.64) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL9856946 | 0.96 | HMGCR (0.61) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL9856838 | 0.95 | HMGCR (0.60) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL9857159 | 0.94 | HMGCR (0.59) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL9857215 | 0.94 | HMGCR (0.59) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL9856789 | 0.89 | — | — | |
| SCHEMBL9856756 | 0.84 | HMGCR (0.52) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL4103858 | 0.84 | HMGCR (0.51) | HMGCRNR1I2ABCB11RHOCCYP3A4 | |
| SCHEMBL9856801 | 0.83 | HMGCR (0.65) | HMGCR | |
| SCHEMBL4098730 | 0.83 | HMGCR (0.51) | HMGCRNR1I2ABCB11RHOCCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436851-A1 | Compounds active as inhibitors of the enzyme HMG-CoA reductase and pharmaceutical compositions containing them | ZAMBON GROUP S.p.A. (IT) | 1991-07-17 | — | — | EP | disclosed |