Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 4/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | THPO | P40225 | 1/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | PTGER1 | P34995 | 8/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11829581 | 0.90 | PTGER2 (0.94) | PTGER2MAPTMEN1ALDH1A1CYP1A2 | |
| Pinadoline SCHEMBL29837240 | 0.89 | PTGER2 (1.00) | PTGER2MAPTMEN1ALDH1A1CYP1A2 | |
| Pinadoline SCHEMBL122117 | 0.89 | PTGER2 (1.00) | PTGER2MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11839545 | 0.89 | PTGER2 (0.79) | PTGER2MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11831961 | 0.88 | PTGER2 (0.98) | PTGER2MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11835415 | 0.88 | PTGER2 (0.71) | PTGER2MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11825133 | 0.87 | PTGER2 (0.73) | PTGER2MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11832073 | 0.87 | PTGER2 (0.73) | PTGER2MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11538299 | 0.87 | PTGER2 (0.70) | PTGER2MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11825745 | 0.87 | PTGER2 (0.82) | PTGER2MAPTMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0193822-B1 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(thio-, sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4614617-A | Intermediates for 8-chlorodibenz[(b,f)][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides | G. D. SEARLE & CO. (US) | 1986-09-30 | — | — | US | disclosed |
| EP-0193822-A2 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(thio-, sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. Searle & Co. (US) | 1986-09-10 | — | — | EP | disclosed |
| US-4559336-A | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. SEARLE & CO. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4170593-A | ANTIINFLAMMATORY, ANTIDIARRHEA | G. D. SEARLE & CO. (US) | 1979-10-09 | — | — | US | disclosed |
| US-4125532-A | ANTIINFLAMMATORY, ANTIDIARRHEA | G. D. SEARLE & CO. (US) | 1978-11-14 | — | — | US | disclosed |
| US-4045442-A | ANTIINFLAMMATORY, ANTIDIARRHEA | G. D. SEARLE & CO. (US) | 1977-08-30 | — | — | US | disclosed |