Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | POLA1 | P09884 | 1/20 | 0.33 |
| ▸ | POLG | P54098 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | AHCY | P23526 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | HINT1 | P49773 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9858011 | 0.87 | SLC22A6 (0.43) | ABCB11POLA1POLGFAPSLC22A6 | |
| SCHEMBL9684345 | 0.87 | CDK1 (0.41) | CDK1CCNB1CCNE1CDK2NT5E | |
| SCHEMBL9858021 | 0.86 | CDK1 (0.39) | CDK1CCNB1CCNE1CDK2HPRT1 | |
| SCHEMBL9417199 | 0.85 | CDK1 (0.39) | CDK1CCNB1CCNE1CDK2HPRT1 | |
| SCHEMBL9857660 | 0.84 | HPRT1 (0.53) | HPRT1 | |
| SCHEMBL9417208 | 0.83 | CDK1 (0.43) | CDK1CCNB1CCNE1CDK2NT5E | |
| SCHEMBL9858125 | 0.81 | CDK1 (0.41) | CDK1CCNB1CCNE1CDK2NT5E | |
| SCHEMBL9184996 | 0.81 | CDK1 (0.49) | CDK1CCNB1CCNE1CDK2NT5E | |
| SCHEMBL9857620 | 0.78 | HPRT1 (0.35) | HPRT1 | |
| SCHEMBL9685345 | 0.78 | CDK1 (0.40) | CDK1CCNB1CCNE1CDK2HPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | claimed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | claimed |
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | disclosed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | disclosed |