Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HPRT1 | P00492 | 16/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | PNP | P00491 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857691 | 0.91 | BLM (0.50) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9858092 | 0.88 | HPRT1 (0.66) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9857660 | 0.86 | HPRT1 (0.53) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9417143 | 0.85 | MEN1 (0.52) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9858021 | 0.85 | CDK1 (0.39) | HPRT1 | |
| SCHEMBL9857698 | 0.82 | PNP (0.50) | BLMMEN1KMT2AHPRT1PNP | |
| SCHEMBL10970953 | 0.82 | BLM (0.66) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9858312 | 0.82 | FGFR1 (0.49) | CYP3A4 | |
| SCHEMBL9857618 | 0.81 | PNP (0.47) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9417134 | 0.81 | PNP (0.51) | BLMMEN1KMT2AHPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | claimed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | claimed |
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | disclosed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | disclosed |