Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 7/20 | 0.50 |
| ▸ | HPRT1 | P00492 | 9/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLG | P54098 | 2/20 | 0.44 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9858344 | 0.88 | HPRT1 (0.58) | PNPHPRT1POLBPOLGPOLA1 | |
| SCHEMBL9857691 | 0.86 | BLM (0.50) | PNPHPRT1POLBUSP2TSHR | |
| SCHEMBL9858353 | 0.85 | PNP (0.52) | PNPHPRT1POLBUSP2TSHR | |
| SCHEMBL9417134 | 0.83 | PNP (0.51) | PNPHPRT1POLBUSP2TSHR | |
| SCHEMBL9858115 | 0.82 | HPRT1 (0.63) | PNPHPRT1POLBPOLGPOLA1 | |
| SCHEMBL9857602 | 0.82 | BLM (0.52) | PNPHPRT1USP2TSHREDNRA | |
| SCHEMBL9858137 | 0.81 | SLC22A6 (0.47) | POLGPOLA1 | |
| SCHEMBL9857618 | 0.80 | PNP (0.47) | PNPHPRT1POLBUSP2TSHR | |
| SCHEMBL9182617 | 0.80 | TK1 (0.57) | PNPHPRT1USP2TSHREDNRA | |
| SCHEMBL8717128 | 0.78 | POLB (0.68) | PNPHPRT1POLBUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | claimed |
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | disclosed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | disclosed |