Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | POLG | P54098 | 2/20 | 0.55 |
| ▸ | POLA1 | P09884 | 1/20 | 0.55 |
| ▸ | PNP | P00491 | 8/20 | 0.54 |
| ▸ | HPRT1 | P00492 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417161 | 0.94 | POLB (0.59) | POLBPOLGPOLA1PNPHPRT1 | |
| SCHEMBL9858353 | 0.90 | PNP (0.52) | POLBPOLGPOLA1PNPHPRT1 | |
| SCHEMBL9857583 | 0.88 | HPRT1 (0.61) | POLBPOLGPOLA1PNPHPRT1 | |
| SCHEMBL8720393 | 0.85 | POLB (0.72) | POLBPOLGPOLA1PNPHPRT1 | |
| SCHEMBL9417134 | 0.84 | PNP (0.51) | POLBPOLGPOLA1PNPHPRT1 | |
| SCHEMBL9858204 | 0.83 | HPRT1 (0.55) | POLBPOLGPOLA1PNPHPRT1 | |
| SCHEMBL8717524 | 0.83 | POLB (0.81) | POLBPOLGPOLA1PNPHPRT1 | |
| SCHEMBL9683715 | 0.83 | PNP (0.52) | PNPHPRT1MEN1KMT2A | |
| SCHEMBL8742556 | 0.83 | MEN1 (0.48) | POLBPNPHPRT1MEN1KMT2A | |
| SCHEMBL9685484 | 0.82 | PNP (0.53) | PNPHPRT1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | claimed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | claimed |
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | disclosed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | disclosed |