Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 10/20 | 0.47 |
| ▸ | FEN1 | P39748 | 10/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857580 | 0.88 | HTR1A (0.39) | HTR1ASLC6A2SLC6A4SLC6A3ALOX5AP | |
| SCHEMBL10506177 | 0.87 | SPHK2 (0.43) | HTR1ASLC6A2SLC6A4SLC6A3SPHK2 | |
| SCHEMBL9857150 | 0.83 | FEN1 (0.48) | HTR1ASLC6A2SLC6A4SLC6A3ALOX5AP | |
| SCHEMBL9857615 | 0.79 | HTR1D (0.40) | ALOX5APFEN1PTGDR2 | |
| SCHEMBL9857604 | 0.78 | HTR1D (0.39) | — | |
| SCHEMBL9857851 | 0.78 | HTR1D (0.39) | — | |
| SCHEMBL9857677 | 0.78 | HTR1D (0.39) | — | |
| SCHEMBL9857757 | 0.75 | HTR1A (0.47) | HTR1ASLC6A2SLC6A4SLC6A3ALOX5AP | |
| SCHEMBL9857746 | 0.75 | HTR1A (0.47) | HTR1ASLC6A2SLC6A4SLC6A3ALOX5AP | |
| SCHEMBL9857810 | 0.75 | HTR1A (0.54) | HTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0301401-B1 | LEUKOTRIENE ANTAGONISTS, PROCESS FOR THEIR PREPARATION, THEIR USE IN THE TREATMENT OF ILLNESSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-11-27 | — | — | EP | disclosed |
| US-4851440-A | ASTHMA | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-07-25 | — | — | US | disclosed |
| EP-0301401-A2 | Leukotriene antagonists, process for their preparation, their use in the treatment of illnesses | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-01 | — | — | EP | disclosed |