Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10506848 | 1.00 | TSHR (0.42) | TSHRL3MBTL1TDP1PPARGMEN1 | |
| SCHEMBL10506858 | 1.00 | TSHR (0.42) | TSHRL3MBTL1TDP1PPARGMEN1 | |
| SCHEMBL10506785 | 0.95 | PPARG (0.48) | TSHRPPARGALDH1A1CYP3A4MAPK1 | |
| SCHEMBL10506790 | 0.95 | PPARG (0.48) | TSHRPPARGALDH1A1CYP3A4MAPK1 | |
| SCHEMBL9857538 | 0.95 | PPARG (0.48) | TSHRPPARGALDH1A1CYP3A4MAPK1 | |
| SCHEMBL27870235 | 0.82 | SMN1; SMN2 (0.41) | TSHRTDP1PPARGPOLBALOX15 | |
| SCHEMBL10507651 | 0.81 | TSHR (0.44) | TSHRPOLBALDH1A1ATM | |
| SCHEMBL9857520 | 0.81 | TSHR (0.44) | TSHRPOLBALDH1A1ATM | |
| SCHEMBL10507659 | 0.81 | TSHR (0.44) | TSHRPOLBALDH1A1ATM | |
| SCHEMBL9857506 | 0.78 | TSHR (0.43) | TSHRL3MBTL1KMT2AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0301401-B1 | LEUKOTRIENE ANTAGONISTS, PROCESS FOR THEIR PREPARATION, THEIR USE IN THE TREATMENT OF ILLNESSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-11-27 | — | — | EP | disclosed |
| US-4851440-A | ASTHMA | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-07-25 | — | — | US | disclosed |
| EP-0301401-A2 | Leukotriene antagonists, process for their preparation, their use in the treatment of illnesses | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-01 | — | — | EP | disclosed |