Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.30 |
| ▸ | HTR3B | O95264 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.30 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281622 | 0.86 | MAPK1 (0.43) | MAPK1TDP1NOTUMCYP3A4TRPA1 | |
| SCHEMBL11878079 | 0.85 | MAPK1 (0.46) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL1555041 | 0.83 | MAPK1 (0.47) | MAPK1TDP1NOTUMCYP3A4TRPA1 | |
| SCHEMBL1493109 | 0.80 | CYP3A4 (0.55) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL30196175 | 0.80 | KIF11 (0.45) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL4462791 | 0.80 | KIF11 (0.45) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL856525 | 0.79 | MAPK1 (0.61) | MAPK1TDP1NOTUMCYP3A4TRPA1 | |
| SCHEMBL7177146 | 0.78 | MAPK1 (0.46) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL11517806 | 0.77 | MAPK1 (0.52) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL3104369 | 0.76 | CYP3A4 (0.50) | MAPK1TDP1CYP3A4TRPA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153127-B1 | N-ARYL-3-ARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDES, PROCESSES FOR THEIR PRODUCTION, INSECTICIDAL COMPOSITIONS CONTAINING THEM AND METHODS FOR COMBATTING INSECTS | ROHM AND HAAS COMPANY (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4863947-A | PESTICIDES, INSECTICIDES | ROHM AND HAAS (US) | 1989-09-05 | — | — | US | disclosed |
| US-4663341-A | Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides | ROHM AND HAAS COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0153127-A2 | N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides, processes for their production, insecticidal compositions containing them and methods for combatting insects | ROHM AND HAAS COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |