Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15620862 | 0.84 | MAPK1 (0.47) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL29824353 | 0.81 | MAPK1 (0.52) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL161540 | 0.81 | MAPK1 (0.52) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL12600355 | 0.81 | MAPK1 (0.52) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL23801402 | 0.80 | P2RY6 (0.41) | TDP1CYP3A4 | |
| SCHEMBL7158060 | 0.78 | CYP3A4 (0.60) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL29648923 | 0.76 | CYP3A4 (0.58) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL29454784 | 0.76 | MAPK1 (0.68) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL418944 | 0.76 | CYP3A4 (0.58) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL29675170 | 0.76 | CYP3A4 (0.63) | MAPK1TDP1CYP3A4TRPA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1030682-C | Method for preparating N-aryl-3-aryl-4.5-dihydro-IH-pyrazole-l-carboxamides | ROHM AND HASS CORP (US) | 1996-01-17 | — | — | CN | disclosed |
| EP-0153127-B1 | N-ARYL-3-ARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDES, PROCESSES FOR THEIR PRODUCTION, INSECTICIDAL COMPOSITIONS CONTAINING THEM AND METHODS FOR COMBATTING INSECTS | ROHM AND HAAS COMPANY (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4863947-A | PESTICIDES, INSECTICIDES | ROHM AND HAAS (US) | 1989-09-05 | — | — | US | disclosed |
| US-4663341-A | Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides | ROHM AND HAAS COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| CN-85101497-A | Process for the preparation of N-aryl-3-aryl-4, 5-dihydro-1H-pyrazole-1-carboxamides | — | 1986-07-16 | — | — | CN | disclosed |
| EP-0153127-A2 | N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides, processes for their production, insecticidal compositions containing them and methods for combatting insects | ROHM AND HAAS COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |