Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 12/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9859909 | 1.00 | PTAFR (0.41) | PTAFRALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL9859776 | 0.90 | PTAFR (0.42) | PTAFRALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL9859903 | 0.80 | PTAFR (0.45) | PTAFRALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL9859957 | 0.80 | PTAFR (0.45) | PTAFRALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL9099229 | 0.74 | PTAFR (0.43) | PTAFRALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL9859410 | 0.72 | PTAFR (0.63) | PTAFRALDH1A1SMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL10448547 | 0.72 | PTAFR (0.58) | PTAFRALDH1A1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL8109885 | 0.69 | PTAFR (0.61) | PTAFRALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8109884 | 0.69 | PTAFR (0.45) | PTAFRALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL10448821 | 0.69 | PTAFR (0.57) | PTAFRALDH1A1SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010100-A | Skeletal muscular disorders, hydertensive agents, cardiovascular disorders | MERCK & CO. INC. (US) | 1991-04-23 | — | — | US | disclosed |