Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.79 |
| ▸ | BCR | P11274 | 16/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.79 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.79 |
| ▸ | PRKCA | P17252 | 7/20 | 0.79 |
| ▸ | SRC | P12931 | 5/20 | 0.79 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.79 |
| ▸ | PRKCG | P05129 | 1/20 | 0.79 |
| ▸ | PRKCB | P05771 | 1/20 | 0.79 |
| ▸ | PRKCH | P24723 | 1/20 | 0.79 |
| ▸ | PRKCI | P41743 | 1/20 | 0.79 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.79 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.79 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.79 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.79 |
| ▸ | EGFR | P00533 | 1/20 | 0.74 |
| ▸ | ABL2 | P42684 | 1/20 | 0.66 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197 | 0.88 | ABL1 (1.00) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL4903275 | 0.87 | ABL1 (0.81) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL9763 | 0.85 | ABL1 (1.00) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL29498750 | 0.85 | PDGFRA (1.00) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL30197820 | 0.85 | PDGFRA (0.85) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL9782 | 0.85 | PDGFRA (1.00) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL9971 | 0.84 | ABL1 (0.57) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL7469833 | 0.84 | ABL1 (0.81) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| Methane SCHEMBL5972158 | 0.84 | PDGFRA (0.98) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL4903136 | 0.84 | PDGFRA (0.82) | ABL1BCRPDGFRBPDGFRAPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564409-B1 | Pyrimidin derivatives and process for their preparation | NOVARTIS AG (CH) | 2000-01-19 | — | — | EP | disclosed |
| US-5521184-A | ANTITUMOR AGENTS; imatinib mesylate | CIBA-GEIGY CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0564409-A1 | Pyrimidin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-10-06 | — | — | EP | disclosed |