Methane

Methane

SCHEMBL9862054

C.Nc1cccc2c1C(=O)c1ccc(S)cc1C2=O

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 6/20 0.66
PTPRC P08575 2/20 0.51
MAOA P21397 3/20 0.49
MAOB P27338 1/20 0.49
CSNK1A1 P48729 2/20 0.47
CSNK1D P48730 2/20 0.47
CSNK1G1 Q9HCP0 2/20 0.47
FGR P09769 1/20 0.47
PIM1 P11309 1/20 0.47
DYRK1A Q13627 1/20 0.47
HIPK2 Q9H2X6 1/20 0.47
ALDH1A1 P00352 10/20 0.44
MAPK1 P28482 7/20 0.44
SMN1; SMN2 Q16637 6/20 0.44
RAB9A P51151 5/20 0.44
TDP1 Q9NUW8 4/20 0.44
NPC1 O15118 4/20 0.44
CYP3A4 P08684 3/20 0.44
TSHR P16473 2/20 0.44
TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30377911 0.81 ADORA2A (0.72) ADORA2APTPRCMAOAMAOBCSNK1A1
SCHEMBL29361856 0.81 ADORA2A (0.72) ADORA2APTPRCMAOAMAOBCSNK1A1
SCHEMBL8773084 0.81 ADORA2A (0.72) ADORA2APTPRCMAOAMAOBCSNK1A1
SCHEMBL4444783 0.81 ADORA2A (0.72) ADORA2APTPRCMAOAMAOBCSNK1A1
SCHEMBL26348 0.80 ADORA2A (1.00) ADORA2APTPRCMAOAMAOBCSNK1A1
SCHEMBL1557667 0.80 ADORA2A (1.00) ADORA2APTPRCMAOAMAOBCSNK1A1
SCHEMBL29701006 0.80 ADORA2A (1.00) ADORA2APTPRCMAOAMAOBCSNK1A1
Anthraquinone SCHEMBL11781807 0.80 ADORA2A (1.00) ADORA2APTPRCMAOAMAOBCSNK1A1
SCHEMBL31069823 0.79 ADORA2A (0.74) ADORA2APTPRCMAOAMAOBCSNK1A1
SCHEMBL8777849 0.79 ADORA2A (0.68) ADORA2APTPRCMAOAMAOBCSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5026831-A Water-insoluble disazo colorants having hetero-bicyclic methylene-active compounds as coupling component HOECHST AKTIENGESELLSCHAFT (DE) 1991-06-25 US disclosed