Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PCNA | P12004 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25516086 | 0.87 | MEN1 (0.46) | ALDH1A1EPHX2THRBTSHRCASP1 | |
| SCHEMBL23677003 | 0.87 | ALDH1A1 (0.47) | ALDH1A1EPHX2THRBTSHRCASP1 | |
| SCHEMBL9127333 | 0.85 | MCL1 (0.41) | ALDH1A1TSHRHSD17B10MEN1KMT2A | |
| SCHEMBL23518687 | 0.83 | MEN1 (0.46) | ALDH1A1EPHX2THRBTSHRCASP1 | |
| SCHEMBL19261664 | 0.82 | ALDH1A1 (0.42) | ALDH1A1EPHX2THRBTSHRCASP1 | |
| SCHEMBL12743488 | 0.82 | ALDH1A1 (0.42) | ALDH1A1EPHX2THRBTSHRCASP1 | |
| SCHEMBL25516119 | 0.82 | ALDH1A1 (0.42) | ALDH1A1EPHX2THRBTSHRCASP1 | |
| SCHEMBL21172275 | 0.82 | ALDH1A1 (0.42) | ALDH1A1EPHX2THRBTSHRCASP1 | |
| SCHEMBL21172840 | 0.82 | ALDH1A1 (0.42) | ALDH1A1EPHX2THRBTSHRCASP1 | |
| SCHEMBL13034893 | 0.82 | ALDH1A1 (0.42) | ALDH1A1EPHX2THRBTSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | claimed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | claimed |
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |