Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 19/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 19/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 16/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9863951 | 0.86 | SLC6A4 (0.71) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL9864405 | 0.84 | SLC6A4 (0.69) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL9864228 | 0.84 | SLC6A4 (0.69) | SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL9864289 | 0.82 | SLC6A4 (0.60) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| Hydrochloric Acid SCHEMBL10838493 | 0.78 | KCNH2 (0.59) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL9863742 | 0.76 | SLC6A4 (0.69) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL15422677 | 0.74 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL15422779 | 0.74 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9864378 | 0.74 | SLC6A3 (0.62) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL9864269 | 0.73 | SLC6A4 (0.53) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |