Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 17/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 17/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864123 | 0.84 | SLC6A3 (0.57) | SLC6A3SLC6A4SLC6A2KCNH2 | |
| SCHEMBL9863779 | 0.84 | SLC6A3 (0.54) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL9864421 | 0.82 | SLC6A3 (0.56) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL27283870 | 0.82 | SLC6A3 (0.55) | SLC6A3SLC6A4SLC6A2KCNH2 | |
| SCHEMBL9864132 | 0.81 | SLC6A3 (0.53) | SLC6A3SLC6A4SLC6A2KCNH2 | |
| SCHEMBL9864749 | 0.81 | SLC6A3 (0.54) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL9863943 | 0.81 | SLC6A3 (0.50) | SLC6A3SLC6A4SLC6A2KCNH2 | |
| SCHEMBL9863972 | 0.80 | SLC6A3 (0.58) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL9863839 | 0.80 | SLC6A3 (0.50) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL9864680 | 0.79 | SLC6A3 (0.53) | SLC6A3SLC6A4SLC6A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |