Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864070 | 0.76 | CYP1A2 (0.53) | ARTSHRPOLBRAB9APRMT5 | |
| SCHEMBL13226859 | 0.72 | AHR (0.46) | ARCHEK1TSHRPOLBRAB9A | |
| SCHEMBL8404432 | 0.67 | AHR (0.47) | ARCHEK1POLBLMNACYP1A2 | |
| SCHEMBL3654198 | 0.65 | CHEK1 (0.62) | CHEK1POLBKDM4ECYP1A2HTR2A | |
| SCHEMBL18136567 | 0.64 | AHR (0.48) | ARCHEK1TSHRPOLBCYP1A2 | |
| SCHEMBL26373746 | 0.64 | AHR (0.44) | ARCHEK1POLBKDM4ECYP1A2 | |
| SCHEMBL5746944 | 0.64 | CHEK1 (0.46) | ARCHEK1POLBKDM4ECYP1A2 | |
| SCHEMBL20674199 | 0.64 | AHR (0.44) | CHEK1TSHRPOLBRAB9AKDM4E | |
| SCHEMBL3607855 | 0.64 | TRIM24 (0.50) | ARCHEK1TSHRPOLBKDM4E | |
| SCHEMBL29568306 | 0.64 | KDM4E (0.63) | ARCHEK1KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988695-A | Gastrointestinal disorders, antisecretory agents | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-01-29 | — | — | US | disclosed |
| EP-0380257-A2 | Condensed cinnoline derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) | 1990-08-01 | — | — | EP | disclosed |