Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 7/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866341 | 0.77 | KDM4E (0.36) | KDM4ECYP1A2SMN1; SMN2TOP2ATOP2B | |
| SCHEMBL9574531 | 0.71 | KDM4E (0.35) | KDM4ECYP1A2SMN1; SMN2TOP2ATOP2B | |
| SCHEMBL28441029 | 0.71 | KDM4E (0.52) | KDM4ECYP1A2SMN1; SMN2TOP2ATOP2B | |
| SCHEMBL28409035 | 0.71 | KDM4E (0.52) | KDM4ECYP1A2SMN1; SMN2TOP2ATOP2B | |
| SCHEMBL9249913 | 0.69 | KCNH2 (0.41) | KDM4ECYP1A2SMN1; SMN2PIM1GSK3A | |
| SCHEMBL9129061 | 0.68 | PIM1 (0.37) | KDM4ECYP1A2SMN1; SMN2TOP2ATOP2B | |
| SCHEMBL9129070 | 0.68 | PIM1 (0.37) | KDM4ECYP1A2SMN1; SMN2TOP2ATOP2B | |
| SCHEMBL9244385 | 0.68 | KCNH2 (0.41) | KDM4ECYP1A2SMN1; SMN2PIM1GSK3A | |
| SCHEMBL9215466 | 0.68 | KDM4E (0.33) | KDM4ECYP1A2SMN1; SMN2TOP2ATOP2B | |
| SCHEMBL5443905 | 0.68 | TOP2A (0.61) | KDM4ECYP1A2SMN1; SMN2TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992546-A | Process for preparing 6,8-diazabicyclo[3.2.2]nonane derivatives | WARNER-LAMBERT COMPANY (US) | 1991-02-12 | — | — | US | disclosed |
| US-4968799-A | Antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| US-4962108-A | A QUIN-4-ONE HAVING THE FOLLOWING RING SUBSTITUENTS; 1-ALKYL OR PHENYL, 3-CARBOXY DERIVATIVE, 6-FLUORO AND 8-BRIDGED N-HETEROCYCLIC RING | WARNER-LAMBERT COMPANY (US) | 1990-10-09 | — | — | US | disclosed |
| US-4923879-A | CARBOXYLIC ACID DERIVATIVES WITH BRIDGED SIDECHAINS | WARNER-LAMBERT COMPANY (US) | 1990-05-08 | — | — | US | disclosed |
| EP-0305744-A2 | Quinoline, naphthyridine and benzoxazine-carboxylic acid derivatives and their use as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |