SCHEMBL9865248

SCHEMBL9865248

O=C(O)c1ccc2c(c1)C(SCCNS(=O)(=O)c1ccccc1)c1ccccc1OC2

nearest known ligand 0.89

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 18/20 0.89
TBXAS1 P24557 5/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9375506 0.94 TBXA2R (1.00) TBXA2RTBXAS1
SCHEMBL9371340 0.92 TBXAS1 (1.00) TBXA2RTBXAS1
SCHEMBL9377972 0.91 TBXA2R (0.74) TBXA2RTBXAS1
SCHEMBL9374527 0.90 TBXA2R (1.00) TBXA2RTBXAS1
SCHEMBL9371084 0.88 TBXA2R (1.00) TBXA2RTBXAS1
SCHEMBL9371532 0.88 TBXA2R (0.88) TBXA2RTBXAS1
SCHEMBL9371593 0.88 TBXA2R (1.00) TBXA2RTBXAS1
SCHEMBL9372399 0.88 TBXA2R (0.88) TBXA2RTBXAS1
SCHEMBL9371708 0.87 TBXA2R (1.00) TBXA2RTBXAS1
SCHEMBL9864928 0.87 TBXA2R (1.00) TBXA2RTBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5010087-A Cardiovascular disorders KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-04-23 US disclosed
US-5010104-A Antiischemic agent, cardiovascular disorders KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-04-23 US disclosed
US-4882351-A CARDIOVASCULAR DISORDERS; ROUSSEL UCLAF (FR) 1989-11-21 US disclosed