Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | DUT | P33316 | 2/20 | 0.40 |
| ▸ | TK1 | P04183 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | TK2 | O00142 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275984 | 0.79 | KIF11 (0.74) | KIF11DUTTK1HRH4TK2 | |
| SCHEMBL15642136 | 0.76 | KIF11 (0.63) | KIF11DUTTK1HRH4TK2 | |
| SCHEMBL9039609 | 0.76 | KIF11 (0.57) | KIF11DUTTK1HRH4TK2 | |
| SCHEMBL13092422 | 0.75 | KIF11 (0.68) | KIF11DUTHRH4MAPK1TSHR | |
| SCHEMBL6241174 | 0.75 | KIF11 (0.56) | KIF11DUTHRH4MAPK1TSHR | |
| SCHEMBL2350021 | 0.75 | KIF11 (0.56) | KIF11DUTTK1TK2MAPK1 | |
| SCHEMBL1525646 | 0.75 | KIF11 (0.56) | KIF11DUTTK1HRH4TK2 | |
| SCHEMBL28093026 | 0.75 | KIF11 (0.56) | KIF11DUTTK1HRH4TK2 | |
| SCHEMBL5735020 | 0.75 | KIF11 (0.56) | KIF11DUTTK1HRH4TK2 | |
| SCHEMBL40498 | 0.75 | KIF11 (0.50) | KIF11TSHRALOX15CYP2C19SLC6A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011938-A | Antimicrobials | ELI LILLY AND COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| US-4940718-A | BACTERICIDES | ELI LILLY AND COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0202046-A1 | 7-Substituted bicyclic pyrazolidinones | ELI LILLY AND COMPANY (US) | 1986-11-20 | — | — | EP | disclosed |
| US-4172839-A | PROSTAGLANDINS | AMERICAN CYANAMID COMPANY (US) | 1979-10-30 | — | — | US | disclosed |