Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775870 | 1.00 | GAA (0.42) | GAAADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL9865532 | 1.00 | GAA (0.42) | GAAADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL6977457 | 0.89 | GAA (0.40) | GAAADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL1777323 | 0.84 | CHRM5 (0.38) | ADRA2COPRD1DDB1CRBN | |
| SCHEMBL1778000 | 0.82 | CHRM5 (0.41) | ADRA2COPRD1DDB1CRBN | |
| SCHEMBL1776075 | 0.82 | CHRM5 (0.41) | ADRA2COPRD1DDB1CRBN | |
| SCHEMBL1776362 | 0.82 | CHRM5 (0.41) | ADRA2COPRD1DDB1CRBN | |
| SCHEMBL27738412 | 0.82 | CHRM5 (0.41) | ADRA2COPRD1DDB1CRBN | |
| SCHEMBL19044546 | 0.81 | DDB1 (0.38) | DDB1CRBN | |
| SCHEMBL1777778 | 0.79 | ACHE (0.42) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066651-A | Sulfonyl group attached to nitrogen, Alzheimer*s disease, antihypoxic, antiischemic, memory lapses | ADIR ET COMPAGNIE (FR) | 1991-11-19 | — | — | US | disclosed |