Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865877 | 0.89 | MEN1 (0.50) | MEN1KMT2AHDAC1NAMPTNTSR1 | |
| SCHEMBL3955009 | 0.86 | SYK (0.57) | MEN1KMT2ALMNAMAPTSYK | |
| SCHEMBL7302006 | 0.85 | SYK (0.46) | MEN1KMT2ARAB9AMAPTSYK | |
| SCHEMBL7289218 | 0.84 | HDAC1 (0.56) | MEN1KMT2AHDAC1NAMPTNTSR1 | |
| SCHEMBL12913502 | 0.83 | PRSS1 (0.64) | MEN1KMT2AHDAC2RAB9AMAPT | |
| SCHEMBL6288470 | 0.83 | SYK (0.57) | MEN1KMT2AHDAC1NAMPTNTSR1 | |
| SCHEMBL14485285 | 0.82 | SYK (0.62) | MEN1KMT2AHDAC1NAMPTNTSR1 | |
| SCHEMBL31258268 | 0.82 | SYK (0.53) | MEN1KMT2AHDAC1HDAC3HDAC2 | |
| SCHEMBL7308592 | 0.82 | SYK (0.53) | MEN1KMT2AHDAC1HDAC3HDAC2 | |
| SCHEMBL27441071 | 0.81 | PRSS1 (0.69) | MEN1KMT2ARAB9ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039805-A | Novel benzoic and phenylacetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-08-13 | — | — | US | disclosed |
| EP-0372486-A2 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-06-13 | — | — | EP | disclosed |