Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865771 | 0.89 | MEN1 (0.56) | MEN1KMT2ASYKNAMPTPRSS1 | |
| SCHEMBL9335874 | 0.87 | PRMT5 (0.51) | MEN1KMT2AGLANR1H4RAB9A | |
| SCHEMBL3955009 | 0.84 | SYK (0.57) | MEN1KMT2ASYKPRSS1 | |
| SCHEMBL23181123 | 0.83 | RAB9A (0.54) | MEN1KMT2ASYKNR1H4NTSR1 | |
| SCHEMBL9867345 | 0.82 | NAMPT (0.52) | NAMPTNR1H4 | |
| SCHEMBL13999403 | 0.82 | ROCK2 (0.50) | NAMPTPPARGNR1H4ROCK2HDAC1 | |
| SCHEMBL9339394 | 0.81 | CA1 (0.51) | HDAC1RAB9A | |
| SCHEMBL7145264 | 0.80 | MGLL (0.52) | RAB9A | |
| SCHEMBL23782597 | 0.80 | PDE5A (0.45) | NR1H4ROCK2HSP90AA1RAB9A | |
| SCHEMBL30176194 | 0.80 | PDE5A (0.45) | NR1H4ROCK2HSP90AA1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039805-A | Novel benzoic and phenylacetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-08-13 | — | — | US | disclosed |
| EP-0372486-A2 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-06-13 | — | — | EP | disclosed |