Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.62 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.62 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719789 | 0.96 | CYSLTR1 (0.64) | CYSLTR1GPBAR1CYSLTR2ALOX5MAPK1 | |
| SCHEMBL10544630 | 0.84 | CYSLTR1 (0.84) | CYSLTR1GPBAR1CYSLTR2ALOX5MAPK1 | |
| SCHEMBL9719800 | 0.83 | CYSLTR1 (0.70) | CYSLTR1GPBAR1CYSLTR2ALOX5MAPK1 | |
| SCHEMBL1695058 | 0.80 | CYSLTR1 (0.69) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| Ammonia Solution, Strong SCHEMBL9585183 | 0.80 | CYSLTR1 (0.69) | CYSLTR1GPBAR1CYSLTR2ALOX5MAPK1 | |
| SCHEMBL29587847 | 0.80 | CYSLTR1 (0.68) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL9447067 | 0.79 | AR (0.64) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL2560907 | 0.79 | CYSLTR1 (0.67) | CYSLTR1GPBAR1CYSLTR2ALOX5TP53 | |
| SCHEMBL3271578 | 0.78 | CYSLTR1 (0.69) | CYSLTR1GPBAR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL29426330 | 0.77 | CYSLTR1 (0.78) | CYSLTR1GPBAR1CYSLTR2ALOX5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045547-A | Leukotriene-inhibiting substituted (quinolin-2-yl-methoxy)phenyl-N,N'-sulphonylureas and use thereas | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | disclosed |
| EP-0387610-A2 | Substituted (quinolin-2-yl methoxy)phenyl-N,N'-sulphonyl ureas, processes for their preparation and their use in medicines | BAYER AG (DE) | 1990-09-19 | — | — | EP | disclosed |