Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.33 |
| ▸ | PARG | Q86W56 | 2/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | MC4R | P32245 | 2/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCH | P24723 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865955 | 1.00 | ACHE (0.38) | ACHEALKIRAK4CRBNPARG | |
| SCHEMBL1777323 | 0.84 | CHRM5 (0.38) | ALKCRBNDDB1 | |
| SCHEMBL27717333 | 0.83 | ACHE (0.42) | ACHEALKDRD2DRD4DRD3 | |
| SCHEMBL1777778 | 0.83 | ACHE (0.42) | ACHEALKDRD2DRD4DRD3 | |
| SCHEMBL27738412 | 0.82 | CHRM5 (0.41) | ALKCRBNDDB1HRH3 | |
| SCHEMBL1776075 | 0.82 | CHRM5 (0.41) | ALKCRBNDDB1HRH3 | |
| SCHEMBL1778000 | 0.82 | CHRM5 (0.41) | ALKCRBNDDB1HRH3 | |
| SCHEMBL1776362 | 0.82 | CHRM5 (0.41) | ALKCRBNDDB1HRH3 | |
| SCHEMBL23277816 | 0.82 | ALK (0.34) | ALKIRAK4 | |
| SCHEMBL1775377 | 0.82 | DAO (0.38) | ALKIRAK4CRBNDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103848814-B | The full ketone derivatives of substituted indole as tyrosine kinase inhibitor | 山东亨利医药科技有限责任公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103848814-A | Substituted indole ketone derivative as tyrosine kinase inhibitor | KBP BIOSCIENCES CO LTD | 2014-06-11 | — | — | CN | disclosed |
| US-5066651-A | Sulfonyl group attached to nitrogen, Alzheimer*s disease, antihypoxic, antiischemic, memory lapses | ADIR ET COMPAGNIE (FR) | 1991-11-19 | — | — | US | disclosed |