Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATP4A | P20648 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ATP4B | P51164 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9867337 | 0.99 | HRH2 (0.43) | HRH2HRH4HRH3SLC47A1MEN1 | |
| SCHEMBL9866179 | 0.89 | HRH2 (0.44) | HRH2HRH4HRH3SLC47A1MEN1 | |
| Hydrochloric Acid SCHEMBL9865309 | 0.88 | HRH2 (0.44) | HRH2HRH4HRH3SLC47A1MEN1 | |
| SCHEMBL9866641 | 0.85 | HRH2 (0.52) | HRH2HRH4HRH3SLC47A1MEN1 | |
| SCHEMBL9865800 | 0.85 | HRH2 (0.52) | HRH2HRH4HRH3SLC47A1MEN1 | |
| SCHEMBL9866518 | 0.85 | HRH2 (0.52) | HRH2HRH4HRH3SLC47A1MEN1 | |
| Hydrochloric Acid SCHEMBL9866725 | 0.85 | HRH4 (0.41) | HRH2HRH4HRH3SLC47A1MEN1 | |
| Hydrochloric Acid SCHEMBL9867631 | 0.83 | HRH2 (0.43) | HRH2HRH4HRH3SLC47A1MEN1 | |
| Impromidine SCHEMBL3334460 | 0.81 | HRH2 (0.59) | HRH2HRH4HRH3SLC47A1MEN1 | |
| Impromidine SCHEMBL11039350 | 0.81 | HRH2 (0.59) | HRH2HRH4HRH3SLC47A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |