Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.73 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.73 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019520 | 0.89 | ADRB2 (0.72) | ADRB2ADRB1ADRB3KCNH2KDM4E | |
| SCHEMBL2019519 | 0.89 | ADRB2 (0.72) | ADRB2ADRB1ADRB3KCNH2KDM4E | |
| SCHEMBL2019517 | 0.89 | ADRB2 (0.72) | ADRB2ADRB1ADRB3KCNH2KDM4E | |
| SCHEMBL2022251 | 0.87 | KCNH2 (0.78) | ADRB2ADRB1ADRB3KCNH2MAPT | |
| SCHEMBL2022248 | 0.87 | KCNH2 (0.78) | ADRB2ADRB1ADRB3KCNH2MAPT | |
| SCHEMBL2022249 | 0.87 | KCNH2 (0.78) | ADRB2ADRB1ADRB3KCNH2MAPT | |
| SCHEMBL2020741 | 0.86 | ADRB2 (0.92) | ADRB2ADRB1ADRB3KCNH2MAPT | |
| SCHEMBL2020739 | 0.86 | ADRB2 (0.92) | ADRB2ADRB1ADRB3KCNH2MAPT | |
| SCHEMBL2020737 | 0.86 | ADRB2 (0.92) | ADRB2ADRB1ADRB3KCNH2MAPT | |
| SCHEMBL8781535 | 0.84 | ADRB2 (1.00) | ADRB2ADRB1ADRB3KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994459-A | Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-02-19 | — | — | US | disclosed |