Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877991 | 0.85 | CYSLTR1 (0.52) | PSMB5CYSLTR2CYSLTR1CYP1A2NCF1 | |
| SCHEMBL11180126 | 0.80 | CYSLTR1 (0.45) | PSMB5CYSLTR2CYSLTR1CYP1A2PRNP | |
| SCHEMBL5594071 | 0.79 | CYSLTR1 (0.46) | PSMB5CYSLTR2CYSLTR1CYP1A2CYP2D6 | |
| SCHEMBL11189914 | 0.76 | PSMB5 (0.51) | PSMB5CYSLTR2CYSLTR1CYP1A2PRNP | |
| SCHEMBL30285321 | 0.76 | PDE10A (0.50) | CYSLTR2CYSLTR1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL2305245 | 0.76 | PDE10A (0.50) | CYSLTR2CYSLTR1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29899422 | 0.75 | CYSLTR1 (0.53) | CYSLTR2CYSLTR1CYP1A2CYP3A4NCF1 | |
| SCHEMBL506666 | 0.75 | CYSLTR1 (0.53) | CYSLTR2CYSLTR1CYP1A2CYP3A4NCF1 | |
| SCHEMBL12795599 | 0.75 | PRNP (0.61) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL23844622 | 0.74 | CYP1A2 (0.52) | CYSLTR2CYSLTR1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| US-4634701-A | Furan derivatives having anti-ulcer activity | AUSONIA FARMACEUTICI S.R.L. (IT) | 1987-01-06 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |
| EP-0164040-A2 | Furan derivatives having anti-ulcer activity | AUSONIA FARMACEUTICI S.r.l. (IT) | 1985-12-11 | — | — | EP | disclosed |