Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.78 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.78 |
| ▸ | HRH2 | P25021 | 3/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.47 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29705110 | 0.98 | TDP1 (0.79) | HRH1HRH3HRH4HRH2TDP1 | |
| SCHEMBL10855808 | 0.94 | HRH1 (0.75) | HRH1HRH3HRH4HRH2TDP1 | |
| SCHEMBL11545778 | 0.92 | HRH1 (0.72) | HRH1HRH3HRH4HRH2TDP1 | |
| Hydrochloric Acid SCHEMBL11543895 | 0.92 | TDP1 (0.76) | HRH1HRH3HRH4HRH2TDP1 | |
| 4-Methylhistamine SCHEMBL9456351 | 0.86 | TDP1 (1.00) | HRH1HRH3HRH4HRH2TDP1 | |
| SCHEMBL13263780 | 0.82 | HRH3 (0.62) | HRH1HRH3HRH4HRH2TDP1 | |
| SCHEMBL11041850 | 0.80 | HRH4 (0.60) | HRH1HRH3HRH4HRH2TDP1 | |
| SCHEMBL6678869 | 0.80 | HRH4 (0.60) | HRH1HRH3HRH4HRH2TDP1 | |
| SCHEMBL4905447 | 0.79 | — | — | |
| SCHEMBL24023138 | 0.78 | HRH3 (0.58) | HRH1HRH3HRH4HRH2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |
| US-4166184-A | 2H-IMIDAZOLE-2-THIONE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-08-28 | — | — | US | disclosed |