SCHEMBL9867670

SCHEMBL9867670

COc1ccc(-c2nsc(S(=O)(=O)/N=C/N3CCCCC3)n2)cc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 3/20 0.41
ALDH1A1 P00352 6/20 0.40
KDM4E B2RXH2 2/20 0.40
MAPT P10636 9/20 0.39
HTT P42858 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
FAAH O00519 1/20 0.39
LMNA P02545 1/20 0.37
HPGD P15428 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
TP53 P04637 2/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
ALOX15 P16050 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9867674 1.00 ADORA3 (0.41) ADORA3ALDH1A1KDM4EMAPTHTT
SCHEMBL9869249 0.87 MAPT (0.41) ALDH1A1KDM4EMAPTHTTNPSR1
SCHEMBL9869251 0.87 MAPT (0.41) ALDH1A1KDM4EMAPTHTTNPSR1
SCHEMBL9867817 0.79 ADORA3 (0.44) ADORA3ALDH1A1KDM4EMAPTHTT
SCHEMBL9867476 0.75 MEN1 (0.49) ADORA3ALDH1A1MAPTHTTNPSR1
SCHEMBL9867483 0.75 MEN1 (0.49) ADORA3ALDH1A1MAPTHTTNPSR1
SCHEMBL9867503 0.72 ADORA3 (0.52) ADORA3ALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL9867131 0.70 ADORA3 (0.48) ADORA3ALDH1A1KDM4EMAPTLMNA
SCHEMBL9867125 0.70 ADORA3 (0.48) ADORA3ALDH1A1KDM4EMAPTLMNA
SCHEMBL14755809 0.69 MAPT (0.51) ADORA3ALDH1A1KDM4EMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4873239-A GLAUCOMA TREATMENT HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-10-10 US claimed
US-4985450-A TREATMENT OF GLAUCOMA AVENTIS PHARMACEUTICALS INC. 1991-01-15 US disclosed
US-4873239-A GLAUCOMA TREATMENT HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-10-10 US disclosed
EP-0276822-A1 Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1988-08-03 EP disclosed
US-4758578-A Arylthiadiazolylsulfonamides, pharmaceutical compositions and use HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) 1988-07-19 US disclosed