Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488395 | 0.76 | ADORA3 (0.54) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL2578415 | 0.76 | ADORA3 (0.59) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL10631566 | 0.74 | ADORA3 (0.44) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL10631561 | 0.74 | ADORA3 (0.44) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL1180509 | 0.74 | CYP19A1 (0.59) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL20320398 | 0.74 | ADORA3 (0.55) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9867568 | 0.72 | ADORA3 (0.54) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9867822 | 0.72 | MAPT (0.55) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9867503 | 0.71 | ADORA3 (0.52) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9107820 | 0.70 | ADORA3 (0.58) | ADORA3MAPTTP53SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | claimed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0276822-A1 | Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |