Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ceftazidime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 4/20 | 0.69 |
| ▸ | PGR | P06401 | 4/20 | 0.69 |
| ▸ | PPARG | P37231 | 3/20 | 0.69 |
| ▸ | ESR1 | P03372 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | APEX1 | P27695 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.60 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.60 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoperazone SCHEMBL1963141 | 0.86 | TDP1 (0.65) | NR1I2PGRPPARGESR1TDP1 | |
| SCHEMBL11473844 | 0.86 | NR1I2 (0.85) | NR1I2PGRPPARGESR1TDP1 | |
| SCHEMBL11470422 | 0.86 | NR1I2 (0.85) | NR1I2PGRPPARGESR1TDP1 | |
| SCHEMBL8973849 | 0.85 | NR1I2 (0.74) | NR1I2PGRPPARGESR1TDP1 | |
| Ceftazidime SCHEMBL5594290 | 0.84 | NR1I2 (0.95) | NR1I2PGRPPARGESR1TDP1 | |
| Ceftazidime SCHEMBL5594295 | 0.84 | NR1I2 (0.95) | NR1I2PGRPPARGESR1TDP1 | |
| Ceftazidime SCHEMBL8681094 | 0.84 | NR1I2 (0.74) | NR1I2PGRPPARGESR1TDP1 | |
| Cefsulodin SCHEMBL6250678 | 0.84 | NR1I2 (0.67) | NR1I2PGRPPARGESR1TDP1 | |
| Ceftazidime SCHEMBL715368 | 0.83 | NR1I2 (0.58) | NR1I2PGRPPARGESR1TDP1 | |
| Ceftazidime SCHEMBL28176723 | 0.83 | NR1I2 (0.79) | NR1I2PGRPPARGESR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5001121-A | Cephalosporin compounds and pharmaceutical compositions thereof | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-19 | — | — | US | disclosed |
| US-4956474-A | PHTHALIMIDOOXY OR AMINOXY COMPOUNDS FOR MAKING CEPHALOSPORINS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| US-4866055-A | ANTIBIOTICS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1989-09-12 | — | — | US | disclosed |