Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefoperazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | SLC22A6 | Q4U2R8 | 3/20 | 0.65 |
| ▸ | SLC22A8 | Q8TCC7 | 3/20 | 0.65 |
| ▸ | SLC22A11 | Q9NSA0 | 3/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.59 |
| ▸ | PGR | P06401 | 4/20 | 0.59 |
| ▸ | PPARG | P37231 | 3/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | APEX1 | P27695 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoperazone SCHEMBL28086380 | 0.87 | MAPT (0.75) | TDP1MAPTSLC22A6SLC22A8SLC22A11 | |
| Ceftazidime SCHEMBL9867976 | 0.86 | NR1I2 (0.69) | TDP1MAPTSLC22A6SLC22A8SLC22A11 | |
| Cefoperazone SCHEMBL1832806 | 0.86 | MAPT (0.72) | TDP1MAPTSLC22A6SLC22A8SLC22A11 | |
| Cefoperazone SCHEMBL10692471 | 0.85 | MAPT (0.71) | TDP1MAPTSLC22A6SLC22A8SLC22A11 | |
| Cefoperazone SCHEMBL16093919 | 0.85 | MAPT (0.71) | TDP1MAPTSLC22A6SLC22A8SLC22A11 | |
| Cefoperazone SCHEMBL22532797 | 0.84 | MAPT (0.73) | TDP1MAPTSLC22A6SLC22A8SLC22A11 | |
| Ceftazidime SCHEMBL8507098 | 0.83 | NR1I2 (0.65) | TDP1MAPTHSD17B10NR1I2PGR | |
| Ceftazidime SCHEMBL715368 | 0.81 | NR1I2 (0.58) | TDP1MAPTSLC22A6SLC22A8SLC22A11 | |
| Cefoperazone SCHEMBL537680 | 0.81 | TDP1 (1.00) | TDP1MAPTSLC22A6SLC22A8SLC22A11 | |
| Cefoperazone SCHEMBL18061225 | 0.81 | MAPT (1.00) | TDP1MAPTSLC22A6SLC22A8SLC22A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011069197-A1 | INHALABLE FORMULATIONS | THE UNIVERSITY OF SYDNEY (AU) | 2011-06-16 | — | — | WO | disclosed |