Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GCG | P01275 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13056570 | 0.77 | NQO2 (0.46) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL16992688 | 0.76 | IKBKB (0.53) | SMN1; SMN2MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL28419614 | 0.74 | PIK3CD (0.40) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL7573624 | 0.74 | HDAC1 (0.65) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL2329568 | 0.74 | ALDH1A1 (0.59) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL27822691 | 0.74 | TDP1 (0.52) | SMN1; SMN2MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL19380241 | 0.74 | ALDH1A1 (0.69) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL23723034 | 0.73 | PIK3CD (0.45) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL30858823 | 0.73 | HDAC3 (0.61) | — | |
| SCHEMBL29222038 | 0.73 | HDAC3 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017584-A | Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles, -1,2,3,4-tetrahydroquinolines and -1H-indoles, and methods of use thereas | STERLING DRUG INC. (US) | 1991-05-21 | — | — | US | disclosed |