Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13215874 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2TDP1ALOX15MAPK1HSD17B10 | |
| SCHEMBL7327731 | 0.87 | CYP4A11 (0.43) | SMN1; SMN2TDP1ALOX15MAPK1HSD17B10 | |
| SCHEMBL10739653 | 0.86 | KDM4E (0.42) | SMN1; SMN2TDP1HSD17B10MAPTALDH1A1 | |
| SCHEMBL19211610 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2TDP1ALOX15MAPK1HSD17B10 | |
| SCHEMBL7331494 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2TDP1ALOX15MAPK1HSD17B10 | |
| SCHEMBL19211596 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2TDP1ALOX15MAPK1HSD17B10 | |
| SCHEMBL8684974 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2TDP1ALOX15MAPK1HSD17B10 | |
| SCHEMBL2964830 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2TDP1ALOX15MAPK1HSD17B10 | |
| SCHEMBL7325433 | 0.77 | PSMD10 (0.43) | SMN1; SMN2TDP1HSD17B10MAPTALDH1A1 | |
| SCHEMBL9868836 | 0.76 | SMN1; SMN2 (0.37) | SMN1; SMN2TDP1MAPK1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006570-A | Dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics | LABORATOIRES DELAGRANGE (FR) | 1991-04-09 | — | — | US | disclosed |
| CN-87100978-A | Dihydrobenzofuran-and chroman-carboxamide derivatives, processes for their preparation and their use as neuroleptics | — | 1987-09-16 | — | — | CN | disclosed |