Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868449 | 1.00 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9867384 | 0.87 | MAPT (0.52) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9867392 | 0.87 | MAPT (0.52) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9867544 | 0.86 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9867549 | 0.86 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9867147 | 0.85 | CYP19A1 (0.42) | ALDH1A1SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL9867152 | 0.85 | CYP19A1 (0.42) | ALDH1A1SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL9867023 | 0.85 | NPC1 (0.41) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9867029 | 0.85 | NPC1 (0.41) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9867538 | 0.78 | SMN1; SMN2 (0.45) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | claimed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0276822-A1 | Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |