Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526934 | 0.88 | FGFR1 (0.35) | TSHRNPSR1RXFP1FGFR1CYP11B1 | |
| SCHEMBL3279905 | 0.82 | CTNNB1 (0.46) | FGFR1CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL9869542 | 0.81 | SLC9A1 (0.47) | FGFR1IDO1HTR5APOLBMCHR1 | |
| SCHEMBL9524640 | 0.78 | SLC9A1 (0.38) | FGFR1CYP11B1CYP11B2CYP19A1IDO1 | |
| Nitric Acid SCHEMBL9527186 | 0.77 | NSD2 (0.39) | RXFP1IDO1KMT2ANPC1RAB9A | |
| SCHEMBL7463718 | 0.76 | NPC1 (0.44) | FGFR1CYP11B1CYP11B2IDO1HTR5A | |
| SCHEMBL3279244 | 0.75 | IDO1 (0.41) | NPSR1FGFR1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9664804 | 0.74 | CYP11B1 (0.40) | TSHRNPSR1FGFR1CYP11B1CYP11B2 | |
| SCHEMBL9196161 | 0.74 | IDO1 (0.43) | NPSR1FGFR1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9078567 | 0.72 | FGFR1 (0.41) | NPSR1FGFR1CYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |