Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.76 |
| ▸ | HPGD | P15428 | 7/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.76 |
| ▸ | GLA | P06280 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869931 | 0.86 | KDM4E (0.75) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL10556176 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL18343698 | 0.79 | KDM4E (0.59) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL9468406 | 0.77 | KDM4E (0.74) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL9468353 | 0.76 | KDM4E (0.70) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL10695931 | 0.76 | KDM4E (0.70) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL1007511 | 0.75 | KDM4E (0.62) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL18343696 | 0.74 | KDM4E (0.61) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL24225890 | 0.73 | KDM4E (0.59) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL10334307 | 0.72 | KDM4E (0.61) | KDM4EALDH1A1HPGDMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5013737-A | Hypotensive, anxiolytic, cognitive disorders | AMERICAN CYANAMID COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |