Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | HPGD | P15428 | 3/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.75 |
| ▸ | GLA | P06280 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.45 |
| ▸ | STAT1 | P42224 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869067 | 0.86 | KDM4E (0.76) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL9468353 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL10695931 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL10556176 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL30579799 | 0.80 | KDM4E (0.71) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL9468197 | 0.80 | KDM4E (0.71) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL18343698 | 0.76 | KDM4E (0.59) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL10554497 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL1924280 | 0.73 | CSNK2A1 (0.51) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL1007511 | 0.72 | KDM4E (0.62) | KDM4EALDH1A1HPGDMAPK1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5013737-A | Hypotensive, anxiolytic, cognitive disorders | AMERICAN CYANAMID COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |