Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 15/20 | 0.61 |
| ▸ | TOP2B | Q02880 | 10/20 | 0.61 |
| ▸ | TOP1 | P11387 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9869916 | 0.99 | TOP2A (0.60) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL10371958 | 0.94 | TOP2A (0.60) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL10375156 | 0.93 | TOP2A (0.67) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL10373279 | 0.93 | TOP2A (0.66) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL10373776 | 0.90 | KDM4E (0.62) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL9773748 | 0.89 | TOP1 (0.71) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL10914849 | 0.89 | TOP1 (0.53) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL9869658 | 0.89 | KMT2A (0.69) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL10895749 | 0.88 | TOP1 (0.63) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL8130567 | 0.87 | TOP2A (0.57) | TOP2ATOP2BTOP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0201829-A1 | 1-Aryl-4-quinolone-3-carboxylic acids | BAYER AG (DE) | 1986-11-20 | — | — | EP | claimed |
| US-4981854-A | BACTERICIDES, ANIMAL GROWTH REGUALTORS | BAYER AKTIENGESELLSCHAFT (DE) | 1991-01-01 | — | — | US | disclosed |
| US-4980353-A | BACTERICIDES, ANIMAL GROWTH REGULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1990-12-25 | — | — | US | disclosed |
| EP-0154780-B1 | QUINOLINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4774246-A | 6,8-DIFLUORO-4-OXO-3-CARBOXYLIC ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1988-09-27 | — | — | US | disclosed |
| EP-0201829-A1 | 1-Aryl-4-quinolone-3-carboxylic acids | BAYER AG (DE) | 1986-11-20 | — | — | EP | disclosed |
| US-4617308-A | 7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-10-14 | — | — | US | disclosed |
| EP-0154780-A1 | Quinoline antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-09-18 | — | — | EP | disclosed |