SCHEMBL9870323

SCHEMBL9870323

CC(=CC(=O)c1ccc(Cl)c(Cl)c1)N(C)C

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.56
MAPT P10636 5/20 0.56
CYP1A2 P05177 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2C19 P33261 1/20 0.55
KMT2A Q03164 3/20 0.54
HTT P42858 1/20 0.54
TSHR P16473 1/20 0.47
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
POLB P06746 1/20 0.44
APEX1 P27695 1/20 0.42
ALOX5 P09917 1/20 0.42
SRD5A2 P31213 1/20 0.42
MEN1 O00255 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
CXCL12 P48061 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9870320 1.00 ALDH1A1 (0.56) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19
SCHEMBL10556115 0.81 CYP1A2 (0.65) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19
SCHEMBL10556110 0.81 CYP1A2 (0.65) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19
SCHEMBL728234 0.78 TSHR (0.53) MAPTCYP1A2CYP3A4CYP2C19KMT2A
SCHEMBL726466 0.78 TSHR (0.53) MAPTCYP1A2CYP3A4CYP2C19KMT2A
SCHEMBL9193565 0.77 TSHR (0.55) MAPTKMT2AHTTTSHRNPC1
SCHEMBL3012426 0.76 MAPT (0.56) MAPTKMT2ATSHRNPC1RAB9A
SCHEMBL10558030 0.75 ALDH1A1 (0.77) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19
SCHEMBL10558036 0.75 ALDH1A1 (0.77) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19
SCHEMBL14069230 0.75 CYP1A2 (0.67) ALDH1A1MAPTCYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5037980-A Anxiolytic agents, hypotensive agents AMERICAN CYANAMID COMPANY (US) 1991-08-06 US disclosed