Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | KDM6A | O15550 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM5C | P41229 | 1/20 | 0.50 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.50 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.50 |
| ▸ | COMT | P21964 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | DBH | P09172 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118709 | 0.78 | KDM4E (0.57) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL4542085 | 0.73 | KDM4E (0.55) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL13759838 | 0.70 | KDM4E (0.61) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL2115732 | 0.69 | KDM4E (0.55) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL13386378 | 0.68 | KDM4E (0.49) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL2117161 | 0.68 | KDM4E (0.49) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL12249885 | 0.68 | KDM4E (0.53) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| Deferiprone SCHEMBL20775057 | 0.67 | KDM4E (1.00) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| Deferiprone SCHEMBL94474 | 0.67 | KDM4E (1.00) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL13555552 | 0.67 | KDM4E (0.47) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011000104-A1 | FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES | APOTEX TECHNOLOGIES INC. (CA) | 2011-01-06 | — | — | WO | disclosed |