Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870801 | 1.00 | MTNR1A (0.51) | MTNR1AMTNR1BCYP19A1AKR1C1TRPA1 | |
| SCHEMBL22501039 | 0.88 | CYP19A1 (0.48) | MTNR1AMTNR1BCYP19A1 | |
| SCHEMBL22501036 | 0.88 | CYP19A1 (0.48) | MTNR1AMTNR1BCYP19A1 | |
| SCHEMBL14785488 | 0.81 | MTNR1A (0.47) | MTNR1AMTNR1BCYP19A1AKR1C1TRPA1 | |
| SCHEMBL3577072 | 0.80 | HDAC3 (0.53) | MTNR1AMTNR1BCYP19A1AKR1C1PRMT1 | |
| SCHEMBL3577068 | 0.80 | HDAC3 (0.53) | MTNR1AMTNR1BCYP19A1AKR1C1PRMT1 | |
| SCHEMBL3577074 | 0.80 | HDAC3 (0.53) | MTNR1AMTNR1BCYP19A1AKR1C1PRMT1 | |
| SCHEMBL11712615 | 0.78 | HDAC1 (0.55) | MTNR1AMTNR1BCYP19A1AKR1C1 | |
| SCHEMBL8871810 | 0.78 | MTNR1A (0.51) | MTNR1AMTNR1BCYP19A1AKR1C1GSK3B | |
| SCHEMBL5157146 | 0.78 | MTNR1A (0.51) | MTNR1AMTNR1BCYP19A1AKR1C1PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068325-A | Dopaminergic systems as hypotensives, sedatives, antitussives and/or antiphlogistics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |
| US-4013643-A | N,N-DISUBSTITUTED 2,3-DIPHENYLALLYLAMINES | G. D. SEARLE & CO. (US) | 1977-03-22 | — | — | US | disclosed |