Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.61 |
| ▸ | TOP1 | P11387 | 4/20 | 0.61 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10702973 | 0.96 | TOP2A (0.58) | TOP2ATOP1TOP2BKDM4EALDH1A1 | |
| SCHEMBL9870380 | 0.91 | KDM4E (0.64) | TOP2ATOP1TOP2BKDM4EALDH1A1 | |
| SCHEMBL10769256 | 0.90 | TOP2A (0.59) | TOP2ATOP1TOP2BKDM4EALDH1A1 | |
| SCHEMBL9773828 | 0.90 | TOP2A (0.57) | TOP2ATOP1TOP2BKDM4EALDH1A1 | |
| SCHEMBL9662901 | 0.90 | TOP2A (0.59) | TOP2ATOP1TOP2BKDM4EALDH1A1 | |
| SCHEMBL9871193 | 0.89 | KDM4E (0.64) | TOP2ATOP1KDM4EALDH1A1HPGD | |
| SCHEMBL9662381 | 0.89 | TOP2A (0.56) | TOP2ATOP1TOP2BKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9773735 | 0.88 | TOP2A (0.55) | TOP2ATOP1TOP2BKDM4EALDH1A1 | |
| SCHEMBL9870203 | 0.88 | KDM4E (0.66) | TOP2ATOP1TOP2BKDM4EALDH1A1 | |
| SCHEMBL9869967 | 0.88 | KDM4E (0.67) | TOP2ATOP1TOP2BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4981854-A | BACTERICIDES, ANIMAL GROWTH REGUALTORS | BAYER AKTIENGESELLSCHAFT (DE) | 1991-01-01 | — | — | US | disclosed |
| US-4980353-A | BACTERICIDES, ANIMAL GROWTH REGULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1990-12-25 | — | — | US | disclosed |