Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752615 | 0.86 | PDE4B (0.47) | PDE4BPDE4DCYP1A2RAB9ANPC1 | |
| SCHEMBL9752708 | 0.82 | PDE4B (0.44) | PDE4BPDE4DRAB9ANPC1 | |
| SCHEMBL9871984 | 0.81 | PDE4B (0.43) | PDE4BPDE4DRAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL9752508 | 0.81 | PDE4B (0.43) | PDE4BPDE4DRAB9ANPC1 | |
| SCHEMBL9879251 | 0.80 | PDE4B (0.42) | PDE4BPDE4DRAB9ANPC1 | |
| SCHEMBL9752624 | 0.78 | PDE4B (0.45) | PDE4BPDE4D | |
| SCHEMBL9870296 | 0.78 | PDE4B (0.69) | PDE4BPDE4DCYP1A2LMNA | |
| SCHEMBL8576941 | 0.76 | PDE4B (0.44) | PDE4BPDE4D | |
| SCHEMBL9752566 | 0.75 | PDE4B (0.58) | PDE4BPDE4DHRH3 | |
| SCHEMBL9752596 | 0.75 | PDE4B (0.39) | PDE4BPDE4DCYP1A2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985560-A | Pyridazino(4,5-b)indolizines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-15 | — | — | US | disclosed |