Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752708 | 0.83 | PDE4B (0.44) | PDE4BPDE4DMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL9752508 | 0.82 | PDE4B (0.43) | PDE4BPDE4DMEN1KMT2ANPC1 | |
| SCHEMBL9879251 | 0.79 | PDE4B (0.42) | PDE4BPDE4DNPC1RAB9APOLB | |
| SCHEMBL9752624 | 0.77 | PDE4B (0.45) | PDE4BPDE4DKMT2A | |
| SCHEMBL9870800 | 0.77 | PDE4B (0.45) | PDE4BPDE4DMEN1KMT2A | |
| SCHEMBL9871984 | 0.76 | PDE4B (0.43) | PDE4BPDE4DMEN1KMT2ANPC1 | |
| SCHEMBL9752615 | 0.76 | PDE4B (0.47) | PDE4BPDE4DCYP1A2NPC1RAB9A | |
| SCHEMBL9871514 | 0.76 | PDE4B (0.41) | PDE4BPDE4DKMT2ANPC1RAB9A | |
| SCHEMBL8576941 | 0.75 | PDE4B (0.44) | PDE4BPDE4DPOLB | |
| SCHEMBL9871483 | 0.75 | PDE4B (0.46) | PDE4BPDE4DCYP1A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991010664-A1 | PYRIDAZINO[4,5-b]INDOLIZINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-07-25 | — | — | WO | disclosed |
| US-4985560-A | Pyridazino(4,5-b)indolizines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-15 | — | — | US | disclosed |