Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10436139 | 0.78 | TSHR (0.48) | TSHRALDH1A1KDM4EDRD2MEN1 | |
| SCHEMBL5077812 | 0.69 | TSHR (0.50) | TSHRALDH1A1KDM4EMAPTDRD2 | |
| SCHEMBL28920791 | 0.68 | LRRK2 (0.41) | TSHRALDH1A1CYP1A2CYP2C19POLB | |
| SCHEMBL4631186 | 0.67 | CHRM1 (0.39) | — | |
| SCHEMBL31743110 | 0.66 | TSHR (0.59) | TSHRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13770253 | 0.66 | ALDH1A1 (0.55) | TSHRALDH1A1KDM4EDRD2MEN1 | |
| SCHEMBL7294568 | 0.65 | KMT2A (0.42) | ALDH1A1MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL7294575 | 0.65 | KMT2A (0.42) | ALDH1A1MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL7294562 | 0.65 | KMT2A (0.42) | ALDH1A1MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL3815610 | 0.65 | CPT2 (0.65) | ALDH1A1KDM4EDRD2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057525-A | Stimulators of gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-10-15 | — | — | US | disclosed |
| US-4962115-A | Stimulate motility of gastrointestinal system | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-10-09 | — | — | US | disclosed |
| EP-0076530-B1 | NOVEL N-(3-HYDROXY-4-PIPERIDINYL)BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-12-11 | — | — | EP | disclosed |
| EP-0076530-A2 | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-04-13 | — | — | EP | disclosed |