Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10571228 | 0.90 | ELANE (0.46) | ELANEHPGDGPBAR1MAPTTP53 | |
| SCHEMBL9871782 | 0.88 | ELANE (0.44) | ELANEHPGDGPBAR1TP53 | |
| SCHEMBL11003132 | 0.84 | ELANE (0.44) | ELANEHPGDGPBAR1ALDH1A1LMNA | |
| SCHEMBL10570187 | 0.81 | ELANE (0.51) | ELANEHPGDGPBAR1LMNAMAPT | |
| SCHEMBL9870805 | 0.80 | ELANE (0.48) | ELANEHPGDGPBAR1MAPTL3MBTL1 | |
| SCHEMBL11175452 | 0.76 | ELANE (0.54) | ELANEGPBAR1ALDH1A1 | |
| SCHEMBL9870175 | 0.72 | ELANE (0.58) | ELANEGPBAR1ALDH1A1 | |
| SCHEMBL9871240 | 0.71 | TDP1 (0.47) | ELANEALDH1A1 | |
| SCHEMBL9870539 | 0.70 | ELANE (0.56) | ELANEHPGDGPBAR1ALDH1A1 | |
| SCHEMBL10643690 | 0.68 | ELANE (0.47) | ELANEGPBAR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021566-A | Carbapenicillins; preservatives; antiseptics; grampositive and gram negative bacteria | MERCK & CO. INC. (US) | 1991-06-04 | — | — | US | disclosed |
| US-4745188-A | ANTIBIOTICS, SULFIDING | MERCK & CO., INC. (US) | 1988-05-17 | — | — | US | disclosed |
| US-4707547-A | AMINATION TO FORM ANTIBIOTIC | MERCK & CO., INC. (US) | 1987-11-17 | — | — | US | disclosed |
| US-4530841-A | Antibiotic containing hetero ring | MERCK & CO., INC. (US) | 1985-07-23 | — | — | US | disclosed |