Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.37 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.31 |
| ▸ | ANPEP | P15144 | 3/20 | 0.31 |
| ▸ | LAP3 | P28838 | 2/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28360125 | 0.86 | CACNA2D1 (0.50) | SLC22A6CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL28360126 | 0.86 | CACNA2D1 (0.50) | SLC22A6CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL15988236 | 0.79 | SLC22A6 (0.37) | SLC22A6RNPEPSLC7A5GRIA1ANPEP | |
| SCHEMBL28070675 | 0.77 | SLC22A6 (0.43) | SLC22A6GRIA1GABBR2GABBR1 | |
| SCHEMBL5374 | 0.77 | — | — | |
| SCHEMBL12522477 | 0.77 | SLC22A6 (0.36) | SLC22A6RNPEPSLC7A5GRIA1ANPEP | |
| SCHEMBL7053481 | 0.76 | SLC22A6 (0.48) | SLC22A6GABBR2GABBR1 | |
| SCHEMBL6034381 | 0.75 | ANPEP (0.42) | SLC22A6CACNA2D1CACNB3CACNA1CSLC7A5 | |
| SCHEMBL27320171 | 0.75 | ANPEP (0.42) | SLC22A6CACNA2D1CACNB3CACNA1CSLC7A5 | |
| SCHEMBL27422167 | 0.75 | ANPEP (0.42) | SLC22A6CACNA2D1CACNB3CACNA1CSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011848-A | Cardiovascular disorders, hypotensive agents | GLAXO, S.P.A. (IT) | 1991-04-30 | — | — | US | disclosed |
| US-4801599-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | GLAXO S.P.A. (IT) | 1989-01-31 | — | — | US | disclosed |