Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 20/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.79 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.79 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204262 | 0.93 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Caficrestat SCHEMBL29444132 | 0.89 | AKR1B1 (0.81) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Caficrestat SCHEMBL359604 | 0.89 | AKR1B1 (0.81) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL9871647 | 0.89 | AKR1B1 (0.79) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL49012 | 0.88 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL29353641 | 0.88 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL8505122 | 0.88 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL8129027 | 0.88 | AKR1B1 (0.98) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Govorestat SCHEMBL31081639 | 0.84 | AKR1B1 (0.81) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Govorestat SCHEMBL19747408 | 0.84 | AKR1B1 (0.81) | AKR1B1AKR1B10AKR1A1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996204-A | Antidiabetic agents | PFIZER INC. (US) | 1991-02-26 | — | — | US | disclosed |